Back to those studies

I did another quick google search to see if anything new has popped up on dealing with thin uterine lining especially after chemo and total body radiation.

Nothing new. But I did revisit this article published by Biomed Research International in 2014.

The paper mentions one study that had success with a mix of pentoxifylline (PTX) and tocopherol (Vitamin E) in increasing blood flow to the uterus that had been damaged due to radiation.

One study only looked at 6 women who took hormone replacement but also supplemented with 400mg PTX and 500IU of Vitamin E twice a day for 9 months. “Improvements in endometrial thickness, ( 6.2 v 3.2 mm), myometrial dimensions (44 [±5] x30 [±3] x20 [±2] versus 30 [±7]x  22 [±3] x16 [±2] mm), and diastolic uterine artery flow were observed”.

In another case 18 patients who had endometrial thickness of < 6mm took the same combo of PTX and Vitamin E for 6 months. Of these women five became pregnant during the study, two of those women had previously experience total body irradiation. For all of them, endometrial thickness increased from 4.9 to 6.2 on average.

Even though these sample sizes are really small, I feel that given the evidence it can’t hurt for me to try taking the combo of PTX and Vitamin E now to start boosting blood flow. I have emailed the clinic coordinator to see if she can get in touch with Dr. Go to see if he will agree to write me a Rx for PTX.

The paper also confirmed that I am at higher risk for pregnancy complications.  “Analysis of singleton pregnancies has shown that these women (who previously had total body irradiation) had significantly higher rates of caesarean section (42% versus 16%), preterm delivery (20% versus 6%), and low birth weight singleton offspring (23% versus 6%) compared to the general population”. Hence the recommendation that I be monitored as a high risk pregnancy when the time comes. In that case, at least we will know what to look for and can hopefully address it before it becomes an issue.

In my highly unscientific and totally non-expert opinion, most of these complications can be linked to the damage to the normal blood flow to the uterus.

Without adequate blood flow, the uterine lining will not thicken, any growing baby will not get sufficient nutrients through the blood to be able to grow sufficiently and to term. So it all boils down to boosting blood flow to boost lining and create a more hospitable environment for the embryo.

In previous cycles I have tried increasing my estrace dosage (using both pills and patches) alone but this was minimally helpful. The last round of mock cycles I also added in acupuncture, 400IU Vitamin E, as well as used Sildenafil, and my lining improved. So maybe adding the PTX and upping my Vitamin E dosage will be the last little boost I need to get up to 7mm.

I have already started supplementing with Vitamin E 400IU a day in anticipation. I am now considering increasing my dosage to 1000IU a day and starting PTX. So long as I am given the go ahead by Dr. Go.

Conducting my own little study of 1.

 

 

 

 

 

 

 

 

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